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HSL can catalyze multiple substrates, with studies showing that it can function as a TAG, DAG, retinyl, and cholesterol esterase (39, 76, 77)

Serotonin reuptake inhibition: Enhances satiety signals Reduces appetite Improves mood (reduces emotional eating) Stabilizes cravings Similar to SSRIs but different profile Potency ratios: Why triple inhibition powerful: Attacks weight loss from multiple angles Metabolic + appetite + behavioral changes Synergistic effects stronger than single pathway But also multiplies side effect risks Different from GLP-1 single mechanism Compare to semaglutide mechanism and other weight loss approaches

Its a metabolic one, and most fat loss strategies never address it