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The filtered out B12 from the liver goes into the bile to the duodenum where it goes back into the intestine to join with intrinsic factor and makes another pass through the gut

Still, without making an effort to include B12-rich foods in your diet, it can be difficult to consume enough to keep your metabolism optimized

And just to add another curve ball, low serum levels of vitamin B12 are also associated with a higher risk of autism

Currently, Setmelanotide is being tested as a therapeutic option for rare genetic disorders of obesity such as POMC deficiency, heterozygous deficiency obesity, and POMC epigenetic disorders (30-32)