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Supplementary material The Supplementary Material for this article can be found online at: References 1 DongEDuHGardnerL

Conditions of the screen were analysed using timsTOF fleX (Bruker) coupled to Evosep One (Evosep), the ATP6AP1 KO dataset with timsTOF flex coupled to nanoElute (Bruker) and IP with timsTOF PRO2 (Bruker) coupled to nanoElute (Bruker)