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Abdominal pain and cramping Diarrhea, often with pus and blood Rectal bleeding Urgency to defecate Rectal pain Fatigue (due to mitochondrial involvement) Weight loss Fever Failure to grow (in children) Ulcerative colitis can lead to some severe health complications

Side Effects and Contraindications Common side effects of buprenorphine include (91): Constipation Nausea Headache Insomnia Sweating Serious side effects are rare but can include (91): Respiratory depression Allergic reactions Buprenorphine is contraindicated in individuals with: Severe respiratory insufficiency Acute intoxication with opioids Known hypersensitivity

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