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Firstly, the increased permeability of the mitochondrial membrane caused by the continuous opening of MPTP results in the disruption of membrane potential and interruption of electron transport, resulting in diminished ATP production

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S -Nitrosoglutathione prevents bloodbrain barrier disruption associated with increased matrix metalloproteinase-9 activity in experimental diabetes

183 The liver-specific Bmal1 -knockout mouse model ( Alb-Cre, Bmal1 fl/fl ) confirmed that this time-dependent hypoxic response strictly relies on a functionally intact tissue-intrinsic clock, rather than being solely regulated by systemic signals