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doi: 10.1186/s12974-025-03410-w, 147 ZhangS.TangM

This potent oxidant induces ferroptosis by depleting glutathione (GSH), the cells principal soluble antioxidant, thereby compromising the primary defense against lipid peroxides

The methodologic design of the rescue arm favors the sq methotrexate group, in that, on average, approximately 10% of the subjects in this group received a 25% higher dose of methotrexate than did those in the oral group (who could never receive a dose higher than 15 mg as part of the protocol)