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Bloating and gas still occur but at seemingly lower rates

Type 1 diabetes mellitus (T1DM), also known as insulin-dependent diabetes, is characterized by the autoimmune destruction of pancreatic beta cells, leading to a complete deficiency of insulin and resulting in chronic hyperglycemia (see Figure 1 )

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The mechanism involves iron overload suppressing the expression of bone formation-related transcription factors, including runt-related transcription factor 2 (RunX2), osteocalcin (OCN), and alkaline phosphatase (ALP), which subsequently reduces SLC7A11/GPX4 levels and ultimately induces ferroptosis (Figure 1)