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These changes are associated with increased cardiovascular and metabolic disease risk

Morphologically it is distinct from apoptosis, necrosis and pyroptosis: mitochondria shrink, their membranes become denser and cristae disappear, whereas nuclear architecture remains intact ( Figure 1 , the core mechanism of ferroptosis comprises three inter-locking events: perturbation of iron metabolism, build-up of lipid peroxides, and collapse of the glutathioneglutathione peroxidase 4 (GSHGPX4) antioxidant axis

Figure 1: Schematic version of the two types of sleep: rapid eye movement (REM) sleep, characterized by low-voltage fast electroencephalography (EEG), non- REM (NREM) sleep or slow wave sleep, visible at the level of the EEG as slow waves

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