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Unlike other NOX isoforms that require activation by cytosolic subunits, NOX4 is constitutively active and widely expressed in epithelial cells, fibroblasts, endothelial cells, and macrophages

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The electron transport chain (ETC) is a continuous reaction system consisting of four membrane protein complexes and lipid-soluble electron carriers in a certain order, used to convert the reduction potential into a proton gradient across the membrane, accompanied by electron transfer to bind to oxygen molecules and produce water and generate adenosine triphosphate (ATP) for energy