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The results for WARIS II are provided in the following table8: In a prospective, randomized, open label, positive-controlled study9in 254 patients, the thromboembolic-free interval was found to be significantly greater in patients with mechanical prosthetic heart valves treated with warfarin alone compared with dipyridamole-aspirin (p 4.0), age 65, highly variable INRs, history of gastrointestinal bleeding, hypertension, cerebrovascular disease, serious heart disease, anemia, malignancy, trauma, renal insufficiency, concomitant drugs (see PRECAUTIONS) and long duration of warfarin therapy

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Providers must submit detailed narratives explaining why GLP-1 therapy suits individual patient circumstances rather than relying on standard diagnosis codes alone