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PlGF, a member of the VEGF family predominantly expressed in the placenta, is crucial for normal pregnancy

While specific pro-oxidant initiators have not yet been identified, candidates with low oxidation potentials include metals, either derived from device coils or leftover from the manufacturing process, and Furaneol, 4-hydroxy-2,5-dimethyl-furan-3-on, known as strawberry or pineapple furanone, which has a low oxidation potential and has been implicated in the initiation of some cellular metal-dependent radical processes

Collectively, GGCT functions as a metabolic rheostat that orchestrates mitochondrial homeostasis through diverting Gln flux toward glutathione biosynthesis to fortify redox defense, while enhancing Glc-fueled TCA cycle anaplerosis to sustain cell proliferation

In mouse models, the team introduced combined therapy including PD-L1 blocker and cyst(e) inase (a bioengineered enzyme that degrades cystine and cysteine) and such treatment can enhance the efficacy of CTL-mediated anticancer effects, supporting the idea that inducing ferroptosis could be considered a productive way for treating cancer and overcoming immunotherapy resistance (Wang et al., 2019)