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Notably, the lower weight loss (-13.7%) observed in REDEFINE 2 among individuals with T2D suggests that the magnitude of benefit achieved with combined GLP-1 and amylin receptor agonism may depend on the underlying metabolic status, highlighting the need for a more nuanced understanding of the mechanisms governing treatment response [13]

In AD, CD11c + microglia and CD206 + BAMs accumulate LDs, particularly near A plaques

Motor associations of iron accumulation in deep grey matter nuclei in Parkinson's disease: a cross-sectional study of iron-related magnetic resonance imaging susceptibility

There are several drug candidates that are in later stage clinical trials which includes PPAR agonists, anti-fibrotic therapies, anti-inflammatory agents, antioxidants, and treatments targeting the gut-liver axis (154)