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its availability for NAD + synthesis can be partially controlled by modulation of purine nucleotide phosphorylase (PNP), which plays a role in purine salvage pathways where purine bases are recycled into nucleotides 24 and in metabolism of the NAD + precursor nicotinamide riboside (NR) 25

Key Benefits: Promotes calcium absorption for strong bones and teeth Supports immune system function and defense Aids in muscle function and reduces risk of falls Supports cardiovascular and heart health May help improve mood and reduce symptoms of depression Plays a role in regulating inflammation Who May Need It

However, in individuals with normal B12 status, additional supplementation does not enhance metabolic rate or promote fat oxidation

However, it is important to note that neurological symptoms can occur even in the absence of anaemia, particularly in patients taking folic acid supplements, which can mask the blood changes whilst neurological damage progresses