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Agnuside, from the extract of Vitex negundo , reduces the expression of key inflammasome components, including NLRP3, caspase-1, and ASC, along with downstream inflammatory cytokines IL-1 and IL-18 and has been effective in alleviating synovitis and fibrosis in knee osteoarthritis models [61]

Thus, depending upon the ability of an individual to metabolize these chemicals, treatment with 17-estradiol alone may not prove equally efficacious to conjugated equine estrogen, estriol or estrone

In: Plant Abiotic Stress Tolerance (pp

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