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ER proteostasis and ER-unfolded protein response (UPR) capacity are reduced under ER reductive stress, thereby promoting senescence

P.AdeyemoA.ZhouJ.LeiL.AdebamowoS

606 By activating autophagy and inhibiting ferroptosis, rapamycin reduces the loss of dopamine neurons in the substantia nigra and improves behavioral symptoms in PD model mice, suggesting that the mutual regulation of ferroptosis and autophagy may provide therapeutic targets for drug therapy of PD