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Description

In Asian populations, such as this family of sisters, the HFE mutation is rarely detected, making awareness of FD in patients with features of genetic iron overload important

Brain Res 1983;275:321-8

Initially, activated M1 microglia drive the inflammatory response by secreting pro-inflammatory cytokines, which contribute to extracellular matrix degradation, disruption of cell integrity, and damage to the BBB [43]