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This observation supports the first interpretation, suggesting that the nozzles in cyanobacteria exist as monomeric rings lacking conventional associated proteins or pilotins when fully assembled

Physiol Rev 1997 Jan

Sustained inflammatory insults induce cumulative DNA damage and epigenetic reprogramming, fostering malignant transformation through two synergistic mechanisms: (1) persistent immune cell activation (neutrophils, macrophages, lymphocytes) and (2) tumor co-option of inflammatory mediators (IL-6, TNF-, COX-2) as metastatic accelerants