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3 cohorts

The other six brains from each group were fixed for histopathological investigation

This effect can be enhanced by the addition in the medium of serine, a substrate of the reaction, making this phenotype a convenient read-out that can be easily monitored and used for drug or genetic screening

2 Ferroptosis overview In 2003, Dolma and colleagues identified a novel compound, Erastin, through synthetic lethality screening designed to discover anticancer agents