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Disruption of NOTCH1-MYC-CD44 Axis Targets Leukemia Initiating Cells (LIC) in T-ALL

Kong J, Zhang Z, Musch MW, Ning G, Sun J, Hart J, Bissonnette M, Li YC

One such innate immune pathway that was discovered over the last two decades is the cGAS-STING signaling cascade, which recognizes cytosolic double-stranded DNA (dsDNA) and triggers the expression of interferons (IFN) and interferon-stimulated genes (ISGs) (101)