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Four prominent mechanisms by which mitochondria communicate with the rest of the cell include the release of cytochrome c to induce cell death, activation of AMP-activated protein kinase (AMPK) to control mitochondrial fission and fusion, production of reactive oxygen species (ROS) to activate transcription factors, and the release of mitochondrial DNA (mtDNA) to activate immune responses 2,3,4,5 (Fig

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Cochrane Database Syst Rev (2012) 9:CD006616.10.1002/14651858.CD006616.pub2 7 FraternaleACrinelliRCasabiancaAPaolettiMFOrlandiCCarloniEet alMolecules altering the intracellular thiol content modulate NF-kB and STAT-1/IRF-1 signalling pathways and IL-12 p40 and IL-27 p28 production in murine macrophages

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