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DNA methylation score as a biomarker in newborns for sustained maternal smoking during pregnancy

Popov 5 , (1)Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, (2)The First Affiliated Hospital, Sun Yat-Sen University, (3)Gilead Sciences, Inc., (4)The First Affiliated Hospital of Sun Yat-Sen University, (5)Harvard Medical School, Boston, MA Background: Apoptosis Signal-regulating Kinase 1 (ASK1) is activated by various pathological stimuli and induce cell apoptosis via downstream p38 activation