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National Research Council (US) Subcommittee on Laboratory Animal Nutrition

Claire and Larrive 2017)

Those with deficiencies may need up to 1,000 mcg daily until levels normalise, then maintenance doses of 25-100 mcg

Multiple studies (in vitro and in vivo) demonstrate the association between IGF-1 deficit and deregulated lipid metabolism, cardiovascular disease, diabetes, and an altered metabolic profile of diabetic patients