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With RF skin tightening, low-frequency radio waves are used to heat the layers of the skin that stimulate collagen production

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H&E staining results further confirmed that the aortic wall thickness of mice treated with FOXO4-DRI was significantly thinner, and ultrasound examination results showed that the PWV of the aorta was slowed down after FOXO4-DRI treatment, indicating better vascular elasticity and significantly improved vascular function compared to the control group (Figures 2D,E)

This agent differs from earlier therapies that were designed to reduce myocardial loading or induce neurohumoral blockade