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Results Association of peptide proteoforms with age, sex and post-mortem interval Nontryptic mass spectrometry was performed on 102 human cortical samples obtained post-mortem from the angular gyri of individuals stratified into four diagnostic classes: neuropathological AD diagnosis with dementia (dementia, 25 participants), neuropathological AD diagnosis without dementia (resilient, 25 participants), no AD or other neurological disease diagnosis with dementia (frail, 26 participants), and a control group with no AD or other neurological disease diagnosis and negligible cognitive decline at time of death (control, 26 participants)
Since Dihexa (HGF pathway) and Semax (BDNF pathway) target independent neurotrophic systems, researchers hypothesize that combining them could produce additive or synergistic effects on synaptic density and cognitive performance
Volume target concentration The target mass divided by concentration gives the liquid volume