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The safety of using GHSs over the short and long term is According to a 2017 review, common side effects of using GHS may include: increased appetite elevated blood sugar levels fluid retention GHSs may also decrease the bodys sensitivity to the hormone insulin, making it more difficult to regulate blood sugar levels

however, in PD patients, it becomes persistent and leads to the accumulation of activated myofibroblasts that alters the healthy structure and function of the peritoneal membrane, thus hindering the effective treatment (Strippoli et al., 2020

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