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Supratherapeutic doses of up to 8 g daily in healthy adults and 6 g daily in stroke patients have been shown to be relatively safe when used for up to 3 days 36, 37, although one case of chronic use at 6 g daily for 14 years has been associated with the later development of cirrhosis 38

extorquens strain DM4 has been isolated from industrial wastewater sludge in Switzerland as part of efforts to characterize microorganisms able to degrade DCM (Glli and Leisinger 1985)

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