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Carotenoids display their antioxidant activity due to singlet oxygen quenching which culminates in excited carotenoids that dispel the newly acquired energy through a series of rotational and vibrational interactions with the solvent, thus returning to the unexcited state and allowing them to quench more radical species

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Furthermore, MDM2 inhibitors have a lower affinity for MDM4 and have inferior efficacy in tumors with amplified MDM4