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A pooled analysis of 1,298 ME/CFS patients from eight trials revealed that CBT was associated with significant reductions in fatigue severity and functional impairment, alongside improvements in physical function [160]

These comprehensive metabolic changes induced by MA242 highlight its broad impact on cellular metabolic pathways, which may have important implications for its biological and therapeutic effects

In addition to the traditional CAR design with a CD28 transmembrane domain (TMD), we introduced a de novo TMD design following a programmable membrane protein (proMP) strategy 16

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