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As with orthotopic and syngeneic tumours, [ 18 F]FSPG retention was higher in the NRF2-mutant xenografts compared to WT (Fig

As CDK5 downregulates FBXO22, which in turn increases PD-L1 levels in NSCLC, this mechanism may also occur in medulloblastoma

We combined these novel patient-derived hepatocyte organoids with primary human portal mesenchyme and human cholangiocyte organoids (h-CholOrgs) from the same patient to generate human periportal assembloids that recapitulate the functional cell interactions and architecture of the in vivo tissue