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Clinical trials are underway to investigate its therapeutic potential, and early results are encouraging

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In summary, hypoxia regulates MSC survival, proliferation, migration, stemness maintenance, differentiation direction, and anti-inflammatory function through the HIF-1/HIF-2 signaling pathway, playing a positive role in disc repair

Cultures were then diluted 1:500 to 1:1,000 in TSB or Seahorse XF DMEM (Agilent) supplemented with 100 mM glucose, 2 mM L-glutamine and 1 mM sodium pyruvate, and dispensed into poly-D-lysine (PDL)-coated Seahorse XF HS miniplates (100 l per well)