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Elevated serum B12 values in serious conditions Maybe the concern for a possible overdose is caused by the knowledge that some life-threatening diseases can be accompanied by a strong increase in the B12 blood value, in some cases to even 30 times the upper reference value

Curcumin administration has been associated with beneficial changes in gut microbiota composition, leading to improved intestinal barrier function and reduced endotoxin levels that may contribute to liver inflammation through toll-like receptor (TLR) pathways

Key remaining questions involve: Where this shift from ferroptosis to necroptosis occur