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Although guidelines suggest cautious use in compensated cirrhosis and avoidance in decompensated liver disease, a large retrospective cohort study found no significant drug-induced liver injury from naltrexone and no attributed decompensations, supporting its use in both compensated and decompensated cirrhosis with close monitoring [120,121]

PCFT , proton coupled folate transporter

As summarized in the same 2013 review, the pre-specified primary endpoint for statistically significant weight change across the dose range and study duration was not met, even as the safety and tolerability picture held [7]

Injectable pH- and temperature-responsive poly(N-isopropylacrylamide-co-propylacrylic acid) copolymers for delivery of angiogenic growth factors