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Microglial polarization and inflammatory mediators after intracerebral hemorrhage

Further research reveals that rhein can alleviate endoplasmic reticulum stress induced by H/R, upregulate GPX4 and SLC7A11 to mitigate lipid peroxidation, reduce renal ferroptosis, and protect against AKI (185)

Unlike simple anti-inflammatory agents that broadly suppress immune responses, GHK-Cu demonstrates the ability to fine-tune inflammatory reactions, enhancing protective aspects while dampening destructive processes

However, the considerable overlap of functions between these receptors is exemplified in breast cancer where it has been suggested that inhibition of both IGF-1R and IR may be required for effective antitumour response ( As well as the hypothalamic pituitary GH axis, IGF-1 secretion is controlled by autocrine/paracrine signals in peripheral tissues