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KEY WORDS : multidrug resistance, mechanisms of cell defense, P-glycoprotein, glutathione S-transferases, apoptosis, p53, Bcl-2 Abbreviations : MDR) multidrug resistance

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ALP levels in breast cancer and other cancers are diametrically opposite, suggesting that ALP functions differently in different tissues

For instance, activating transcription factor 3 (ATF3) binds to the solute carrier family 7 member 11 (SLC7A11) promoter, suppressing SLC7A11 expression, which reduces levels of glutathione (GSH) and glutathione peroxidase 4 (GPX4) and hinders the reduction of lipid peroxides