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10.3389/fmolb.2022.901565 Front

Furthermore, metformin produced an anti-inflammatory effect by decreasing pro-inflammatory cytokines (TNF and IL-6) and suppressing the macrophage response via ATF-3 induction in an AMPK-dependent manner [82]

2016;5(1):e62

It is widely acknowledged that clinically approved therapies, such as statins and PCSK9 inhibitors, offer mechanistic insight into LDLR regulation by altering cholesterol metabolism and arresting LDLR lysosomal degradation