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the CNS pathology is one of a neurodegenerative disorder, such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), cerebrovascular accidents (CVA: ischemic stroke, intracerebral hemorrhage (ICH) or subarachnoid hemorrhage (SAH)), vascular-related dementia, brain trauma (traumatic brain injury), spinal cord injury, alcoholism, Prion diseases: Creutzfeldt- Jakob disease (CJD), bovine spongiform encephalopathy (BSE)

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[91], their tuneable PL enables high contrast fluorescence imaging, however, challenges relating to in vivo stability, biodistribution, and long-term safety remains key barriers to clinical translation [91]