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10.1016/j.fct.2021.112045 46 ChatsudthipongV.MuanprasatC

18, 19, 20, 21, 22 Recent efforts have proposed that specific transcription factors such as T-bet were associated with T-cell exhaustion, which were supported by the evidence that T-bet directly repressed transcription of the gene encoding PD-1, and high T-bet expression sustained exhausted CD8 + T cells in mice infected with LCMV, 23 reminiscent of its role in sustaining exhausted CD4 + T cells

If a patient shows flu-like symptoms and has a travel history to a country or area with confirmed nCOVID-19 cases or if the patient came into close contact with a confirmed nCOVID-19 patient in the last 14 days then the patient ought to be considered as a patient under investigation (PUI) (NPR, 2020)