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No digestion requiredideal for sensitive systems

This review aims to summarize the role of the oxidative stress in the pathogenesis of AD, focusing in the main oxidative products (DNA, protein, and lipid oxidation products), as well as antioxidant therapeutic approaches involving natural products, nanomaterials, hydrogels, and microneedles

Peripheral blood mononuclear cells (PBMC) were isolated from the buffy coats by density-gradient centrifugation using Ficoll-Paque Plus (GE Healthcare, Little Chalfont, UK)