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Both groups followed a reduced-calorie diet, increased physical activity, and monthly nutritional counseling

Therefore, our findings showing that ubiquitylated IL-1, akin to the IL-1 K133A or D129A mutants, is inefficiently cleaved by Caspase-1 raises the interesting possibility that IL-1 K133 ubiquitylation impacts the integrity of the K133:D129 electrostatic interaction to limit caspase-1 processing

[DOI] [PMC free article] [PubMed] [Google Scholar] 200.Hou Y., Li X., Liu C., Zhang M., Zhang X., Ge S., Zhao L

Reciprocal metabolic reprogramming through lactate shuttle coordinately influences tumor-stroma interplay