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Human clinical data is limited

doi: 10.1016/j.biopha.2019.108671 58

Preclinical studies suggest it can protect nerve cells (neuroprotective effects)

NNMT inhibitors are selective and do not impact related methyltransferases or enzymes in the NAD + salvage pathway The selectivity of NNMT inhibitors was confirmed by testing against a panel of structurally similar methyltransferases and two enzymes in the NAD + salvage pathway (NAMPT and SIRT1