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Across multiple disease areas, discussions increasingly focused not only on whether treatments work under controlled study conditions, but also on how they perform in diverse patient populations, how they impact quality of life, and how healthcare systems can generate evidence that supports more informed clinical, regulatory, and reimbursement decisions

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If the patient is aware of the change in their cognitive capacity, personality and mental state after an injury, they might feel disconnected from their pre-injury identity, leading to irritability, emotional distress and a disrupted concept of self