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Severe or blood glucose confirmed symptomatic hypoglycemia (glucose of 56 mg/dL or less) was not reported in any of the patients receiving semaglutide monotherapy compared to 1.6% of patients receiving placebo

Med 10.1056/NEJMoa2306434 (2023)

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Approximately 20% is absorbed directly through the stomach wall , while the remaining 80% is absorbed through the small intestine specifically the upper portion known as the duodenum