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In addition, SREBP1c indirectly contributes to the development of hepatic insulin resistance, since enhanced lipogenesis and subsequent accumulation of harmful lipid species, such as diacylglycerides, may interfere with insulin signaling (as discussed below)

That can introduce variability such as: Mislabeling Contamination Inconsistent dosing Unknown impurities Side effects: what we can responsibly say Because robust human safety data are limited, it's hard to give a definitive side-effect profile with meaningful incidence rates