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Within this LLPS, YY1 interacts with transcriptional cofactors such as p300, p65, and CEBPB to enhance IL-6 expression in macrophages (Tsang et al., 2020)

Tari AM, Andreeff M , Kleine HD, Lopez-Berestein G

159161,163,178 In these four studies, a significantly increased risk of developing vitamin B 12 depletion as a result use of acid-lowering medication was identified and data from the two studies evaluating duration of treatment supported the general assumption that long-term use of these drugs is associated with an elevated risk of deficiency of this vitamin, but the results were not conclusive

Additionally, the review comprehensively surveys ongoing clinical trials and potential treatment strategies, envisioning a future where targeting MDSCs could reshape the immune landscape of GBM