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Also, since variability itself is an important biomarker, the variability of the biomarker must be measured repeatedly

Gao BB, Wang L, Li LZ, et al

when a xenobiotic compound binds to and activates the receptor, the complex is translocated to the nucleus, where it binds to the enhancer regions of various biotransformation enzymes, promoting increased expression of P450 enzymes via transcription

PEGylation A common approach for muco-penetrating particles or muco-inert particles involves coating them with brush-like polyethylene glycol (PEG), whose electric neutrality, high flexibility and remarkable hydrophilicity reduce chain entanglement and shield the hydrophobic core 148,149,150,151,152,153,154,155,156,157,158,159,160