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In 2018, a phase III randomized controlled clinical trial referred to as the AYAME study ( was launched with diabetic CKD patients whose CKD stages are Grade 3 or 4 as a successor to the phase II study in Japan

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Ultimately, understanding the mechanisms that compromise the vascular niche is paramount, as a deteriorating microenvironment is increasingly recognized as a permissive factor for the development of age-related clonal hematopoiesis and malignancies such as myelodysplastic syndromes 61

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