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Later work has built on that finding, including a 2023 peer-reviewed review on MOTS-Cs role in metabolic disorders

In organotypic hippocampal slice cultures, Dihexa and Nle-AngIV similarly augmented spinogenesis, with control slices showing 7 spines per 50-m dendrite length, compared to 11 for both Dihexa and Nle-AngIV treated slices [1]

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