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Meta-analytic evidence indicates a significant spatial overlap in gray matter deficits between first-episode schizophrenia and frontotemporal lobar degeneration, particularly in the bilateral caudate, left insula, and bilateral uncus, suggesting either shared vulnerability of these regions or partially overlapping etiologies (193)

In other words, BEAGA/ApoE-PDHD crossed the tight BCECs monolayer much more effectively than BEAGA-PDHD and ApoE-PDHD did, which was then absorbed by the bottom plate-locating G422 cells

Early failures underscored the complexity of ICH, whereas contemporary strategies emphasize antihypertensive therapy, neuroprotective and cytoprotective compounds, antioxidant and anti-inflammatory agents, ferroptosis inhibitors, multifunctional proteins such as HSA, and bioactive natural products

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