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When you take B12 as an injection, you need to have a doctors prescription in order to ensure that there are no harmful interactions with other medications

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Trends in Endocrinology & Metabolism 28(5):340-353

tells the Mayo Clinic, Low levels of B-12 and other B vitamins such as vitamin B-6 and folate may be linked to depression. Studies may be inconclusive, but at the very least, a holistic and integrated approach to ones health in the form of adequate vitamins and nutrients helps achieve a more balanced biology that certainly wont hurt your overall mood