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34,44,45 Immunosuppressive and Other Agents Other treatments that have been tested without any proven clinical benefit or improvement of liver biochemistries include: Azathioprine 46 Budesonide 47 Docosahexaenoic acid 48 Metronidazole 49 Minocycline 50 Mycophenolate mofetil 51 Nicotine 52 Pentoxifylline 53 Pirfenodone 54 Prednisolone 55 Tacrolimus 56 Vancomycin 57 Methotrexate 58,59 Novel Therapies Farnesoid X receptor (FXR) agonists (e.g., obeticholic acid, 6-ethyl chenodeoxycholic acid) and 24-norursodeoxycholic acid, a side-chain-modified UDCA derivate resistant to amidation which undergoes cholehepatic shunting, may be novel treatment options

[DOI] [PMC free article] [PubMed] [Google Scholar] [198].Kelly CM, Gutierrez Sainz L, Chi P, The management of metastatic GIST: current standard and investigational therapeutics, J

doi: 10.1016/j.pharmthera.2010.09.004 179

For instance, Drmic et al